Further electron microscopic study of hereditary corneal edema.

This report presents further observation on the fine structure of hereditary corneal edema. The anterior and middle stroma showed almost normal collagen lamellar formation. In the posterior stroma irregularity of interfibrillary distance icas noted. Cross-sections of collagen fibrils varied in diameter. Tioo Descemet's membranes were found, the second one contained unusual banded materials. Most parts of the second Descemet's membrane were covered with thickened multiformed packed smaller collagen fibrils, and a fibroblastlike cell layer was present on the face of the anterior chamber. These observations support our earlier study which suggested that the morphologic changes occurred during fetal development.